(Z)-Lanoconazole

• CAT Number: I045205
• CAS Number: 101529-65-1
• Molecular Formula: C14H10ClN3S2
• Molecular Weight: 319.83
• Purity: ≥95%
• IUPAC Name: (2Z)-2-[4-(2-chlorophenyl)-1,3-dithiolan-2-ylidene]-2-imidazol-1-ylacetonitrile
• InChI: InChI=1S/C14H10ClN3S2/c15-11-4-2-1-3-10(11)13-8-19-14(20-13)12(7-16)18-6-5-17-9-18/h1-6,9,13H,8H2/b14-12-
• InChIKey: ZRTQSJFIDWNVJW-OWBHPGMISA-N
• SMILES: C1C(S/C(=C(/C#N)\N2C=CN=C2)/S1)C3=CC=CC=C3Cl

(Z)-Lanoconazole（Cat No.:I045205）is an imidazole-class antifungal agent that inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme essential for ergosterol biosynthesis in fungal cell membranes. By blocking ergosterol production, it disrupts membrane integrity and function, leading to fungal cell death. The (Z)-isomer retains potent activity against dermatophytes, yeasts, and molds, making it effective in treating superficial mycoses such as athlete’s foot, ringworm, and candidiasis. (Z)-Lanoconazole is valuable in antifungal research for studying azole drug mechanisms and resistance, with potential applications in developing topical therapies for fungal skin infections.