(Z)-JIB-04

• CAT Number: I007413
• CAS Number: 199596-24-2
• Molecular Formula: C17H13ClN4
• Molecular Weight: 308.76
• Purity: ≥95%
• Synonyms: 5-chloro-N-[(Z)-[phenyl(pyridin-2-yl)methylidene]amino]pyridin-2-amine
• InChI: InChI=1S/C17H13ClN4/c18-14-9-10-16(20-12-14)21-22-17(13-6-2-1-3-7-13)15-8-4-5-11-19-15/h1-12H,(H,20,21)/b22-17-
• InChIKey: YHHFKWKMXWRVTJ-XLNRJJMWSA-N
• SMILES: C1=CC=C(C=C1)/C(=N/NC2=NC=C(C=C2)Cl)/C3=CC=CC=N3

(Z)-JIB-04（Cat No.:I007413）is a small-molecule inhibitor of Jumonji family histone demethylases, enzymes that regulate epigenetic modifications and gene expression. By blocking demethylase activity, it alters histone methylation states, influencing transcriptional programs linked to cancer progression and cellular differentiation. (Z)-JIB-04 has demonstrated potent antiproliferative effects in preclinical cancer models, making it a valuable tool for oncology and epigenetics research. Researchers employ it to study chromatin remodeling, transcriptional regulation, and therapeutic strategies targeting epigenetic enzymes. Its selective activity highlights its importance in drug discovery and mechanistic biology studies.