Z-FG-NHO-BzOME

• CAT Number: I040345
• CAS Number: 180313-86-4
• Molecular Formula: C27H27N3O7
• Molecular Weight: 505.52
• Purity: ≥95%
• Synonyms: [[2-[[(2S)-3-phenyl-2-(phenylmethoxycarbonylamino)propanoyl]amino]acetyl]amino] 4-methoxybenzoate
• InChI: InChI=1S/C27H27N3O7/c1-35-22-14-12-21(13-15-22)26(33)37-30-24(31)17-28-25(32)23(16-19-8-4-2-5-9-19)29-27(34)36-18-20-10-6-3-7-11-20/h2-15,23H,16-18H2,1H3,(H,28,32)(H,29,34)(H,30,31)/t23-/m0/s1
• InChIKey: MWMGBOYXKWUFNQ-QHCPKHFHSA-N
• SMILES: COC1=CC=C(C=C1)C(=O)ONC(=O)CNC(=O)C(CC2=CC=CC=C2)NC(=O)OCC3=CC=CC=C3

Z-FG-NHO-BzOMe(CAT: I040345) is a potent and selective cysteine protease inhibitor, designed to target key enzymes including cathepsin B, cathepsin L, cathepsin S, and papain. Structurally, it features a benzyloxycarbonyl (Z)-protected phenylalanine-glycine dipeptide linked to a hydroxamic acid warhead and a benzyl ester moiety (BzOMe), facilitating high-affinity interaction with cysteine protease active sites. By mimicking native substrates, it effectively blocks proteolytic activity, making it a valuable tool for studying protease function in inflammation, cancer, and tissue remodeling. Z-FG-NHO-BzOMe is ideal for in vitro enzymology, inhibitor profiling, and protease-targeted drug discovery.