For research use only. Not for therapeutic Use.
Z-AEVD-FMK(CAT: R060648) is a cleavable peptide-based linker commonly used in the development of antibody-drug conjugates (ADCs). Designed to target caspase-3, this compound enables site-specific payload release upon enzymatic cleavage in apoptotic cells. The AEVD sequence provides selectivity, while the FMK (fluoromethyl ketone) group ensures effective inhibition of caspase activity, aiding in controlled delivery. Its cleavable nature supports stable circulation and efficient intracellular release of cytotoxic agents. Z-AEVD-FMK is ideal for conjugation strategies aimed at improving the therapeutic index of biologics by minimizing systemic toxicity and enhancing tumor-specific delivery in cancer and immunotherapy research.
| CAS Number | 1135688-47-9 |
| Synonyms | methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxo-4-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]pentanoate |
| Molecular Formula | C28H39FN4O10 |
| Purity | ≥95% |
| IUPAC Name | methyl (4S)-5-[[(2S)-1-[[(3S)-5-fluoro-1-methoxy-1,4-dioxopentan-3-yl]amino]-3-methyl-1-oxobutan-2-yl]amino]-5-oxo-4-[[(2S)-2-(phenylmethoxycarbonylamino)propanoyl]amino]pentanoate |
| InChI | InChI=1S/C28H39FN4O10/c1-16(2)24(27(39)32-20(21(34)14-29)13-23(36)42-5)33-26(38)19(11-12-22(35)41-4)31-25(37)17(3)30-28(40)43-15-18-9-7-6-8-10-18/h6-10,16-17,19-20,24H,11-15H2,1-5H3,(H,30,40)(H,31,37)(H,32,39)(H,33,38)/t17-,19-,20-,24-/m0/s1 |
| InChIKey | CHZRBQFKZDGMTP-CDSYHYPYSA-N |
| SMILES | C[C@@H](C(=O)N[C@@H](CCC(=O)OC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(=O)OC)C(=O)CF)NC(=O)OCC1=CC=CC=C1 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
