(Z)-4EGI-1（Cat No.:I015333）is a small-molecule inhibitor that disrupts the eIF4E–eIF4G interaction, a critical step in cap-dependent mRNA translation initiation. By blocking this protein–protein interaction, (Z)-4EGI-1 selectively reduces translation of oncogenic mRNAs, including those involved in cell growth and survival. It has been widely studied in cancer research as a tool for exploring translational control and developing targeted therapies. Beyond oncology, it provides insights into cellular stress responses and gene regulation. Its ability to modulate protein synthesis makes it valuable for studying translation-dependent disease mechanisms.