CONTACT US
Home > Inhibitors/Agonists>Others> > YU238259
YU238259

YU238259

  • CAT Number: I014763
  • CAS Number: 1943733-16-1
  • Molecular Formula: C22H22ClN3O4S
  • Molecular Weight: 459.945
  • Purity: ≥95%
Inquiry Now

YU238259 (CAT: I014763) is a novel inhibitor of homology-dependent DNA repair. It specifically targets and inhibits the process of DNA repair through homologous recombination, which is an essential mechanism for maintaining genome stability. By blocking homology-dependent DNA repair, YU238259 disrupts the ability of cancer cells to effectively repair DNA damage, leading to genomic instability and potentially sensitizing the cells to other DNA-damaging treatments such as chemotherapy or radiation therapy. YU238259 holds promise as a potential therapeutic agent in the treatment of cancer.

Catalog Number I014763
CAS Number 1943733-16-1
Molecular Formula

C22H22ClN3O4S

Purity 95%
Target DNA Repair inhibitor
Solubility Soluble in DMSO
InChI InChI=1S/C22H22ClN3O4S/c1-30-20-8-10-21(11-9-20)31(28,29)26-14-16-2-4-17(5-3-16)22(27)24-13-12-19-7-6-18(23)15-25-19/h2-11,15,26H,12-14H2,1H3,(H,24,27)
InChIKey BIHURSOREGLQBB-UHFFFAOYSA-N
SMILES C1=CC(OC)=CC=C1S(=O)(=O)NCC1=CC=C(C(=O)NCCC2=CC=C(Cl)C=N2)C=C1
Reference

</br>1: Stachelek GC, Peterson-Roth E, Liu Y, Fernandez RJ 3rd, Pike LR, Qian JM,</br> Abriola L, Hoyer D, Hungerford W, Merkel J, Glazer PM. YU238259 Is a Novel</br> Inhibitor of Homology-Dependent DNA Repair That Exhibits Synthetic Lethality and </br> Radiosensitization in Repair-Deficient Tumors. Mol Cancer Res. 2015</br> Oct;13(10):1389-97. doi: 10.1158/1541-7786.MCR-15-0036. Epub 2015 Jun 26. PubMed </br> PMID: 26116172; PubMed Central PMCID: PMC4618103.</br> </br>

Request a Quote

Contact Us at MuseChem

We are committed to providing you with reliable, cost-effective solutions for your chemical needs, while ensuring your safety and comfort. Our team of experts is always available to answer your questions and help you navigate the complexities of the chemical industry.

Whether you're looking for a specific product or need help with a custom synthesis project, we're here to help you discover a new world of chemical possibilities. Contact us today to learn more about how we can assist you with all of your chemical needs.

Our goal is to make the process of ordering chemicals as seamless and hassle-free as possible. Let us know how we can assist you, and we'll get back to you as soon as possible. We look forward to hearing from you!