For research use only. Not for therapeutic Use.
YMU1（Cat No.:R067078）is a selective small-molecule inhibitor of JMJD3 (KDM6B), a histone demethylase that specifically removes methyl groups from trimethylated lysine 27 on histone H3 (H3K27me3), a key epigenetic mark associated with gene repression. By inhibiting JMJD3, YMU1 stabilizes repressive chromatin states, affecting the transcription of genes involved in inflammation, differentiation, and oncogenesis. It is widely used in epigenetics and immunology research to study macrophage polarization, inflammatory gene expression, and developmental regulation. YMU1 is a valuable tool for exploring histone modification dynamics and developing epigenetic therapies in cancer and inflammatory diseases.
| CAS Number | 902589-96-2 |
| Synonyms | ethyl 4-[2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)acetyl]piperazine-1-carboxylate |
| Molecular Formula | C17H22N4O4S |
| Purity | ≥95% |
| IUPAC Name | ethyl 4-[2-(4,6-dimethyl-3-oxo-[1,2]thiazolo[5,4-b]pyridin-2-yl)acetyl]piperazine-1-carboxylate |
| InChI | InChI=1S/C17H22N4O4S/c1-4-25-17(24)20-7-5-19(6-8-20)13(22)10-21-16(23)14-11(2)9-12(3)18-15(14)26-21/h9H,4-8,10H2,1-3H3 |
| InChIKey | XXUFNNVFZFVKGP-UHFFFAOYSA-N |
| SMILES | CCOC(=O)N1CCN(CC1)C(=O)CN2C(=O)C3=C(S2)N=C(C=C3C)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
