For research use only. Not for therapeutic Use.
YM-244769 dihydrochloride（Cat No.:I015241）is a potent and selective inhibitor of the sodium–calcium exchanger (NCX), a critical membrane transporter regulating intracellular calcium homeostasis. By blocking NCX activity, YM-244769 modulates calcium flux, protecting against calcium overload and associated cellular injury. It has been widely investigated in models of cardiac ischemia/reperfusion injury, arrhythmia, and neuronal excitotoxicity, where calcium dysregulation plays a central role. The dihydrochloride salt enhances solubility and handling, making YM-244769 a valuable research tool in cardiovascular and neuroprotective drug discovery.
| CAS Number | 1780390-65-9 |
| Synonyms | N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]pyridine-3-carboxamide;dihydrochloride |
| Molecular Formula | C26H24Cl2FN3O3 |
| Purity | ≥95% |
| IUPAC Name | N-[(3-aminophenyl)methyl]-6-[4-[(3-fluorophenyl)methoxy]phenoxy]pyridine-3-carboxamide;dihydrochloride |
| InChI | InChI=1S/C26H22FN3O3.2ClH/c27-21-5-1-4-19(13-21)17-32-23-8-10-24(11-9-23)33-25-12-7-20(16-29-25)26(31)30-15-18-3-2-6-22(28)14-18;;/h1-14,16H,15,17,28H2,(H,30,31);2*1H |
| InChIKey | OCKIUNLKEPKCRE-UHFFFAOYSA-N |
| SMILES | C1=CC(=CC(=C1)N)CNC(=O)C2=CN=C(C=C2)OC3=CC=C(C=C3)OCC4=CC(=CC=C4)F.Cl.Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
