YL-939

• CAT Number: I042361
• CAS Number: 3023925-68-7
• Molecular Formula: C25H26N6O
• Molecular Weight: 426.51
• Purity: ≥95%
• Synonyms: 8-(3,6-dihydro-2H-pyran-4-yl)-2-phenyl-6-(1-piperidin-4-ylpyrazol-4-yl)imidazo[1,2-a]pyrazine
• InChI: InChI=1S/C25H26N6O/c1-2-4-18(5-3-1)22-16-30-17-23(20-14-27-31(15-20)21-6-10-26-11-7-21)28-24(25(30)29-22)19-8-12-32-13-9-19/h1-5,8,14-17,21,26H,6-7,9-13H2
• InChIKey: CQPPSOHBTWZQRN-UHFFFAOYSA-N
• SMILES: C1CNCCC1N2C=C(C=N2)C3=CN4C=C(N=C4C(=N3)C5=CCOCC5)C6=CC=CC=C6

YL-939 (Cat No.: I042361) is a small-molecule inhibitor developed to target the Hippo-YAP signaling pathway, which plays a crucial role in regulating cell proliferation, apoptosis, and organ size. Dysregulation of this pathway is associated with various cancers. YL-939 stabilizes 14-3-3σ, a tumor suppressor protein, thereby enhancing its interaction with YAP (Yes-associated protein) and preventing YAP’s nuclear localization and transcriptional activity. By disrupting oncogenic YAP signaling, YL-939 shows promise in preclinical cancer models as a potential therapeutic agent for YAP-driven tumors.

Reference

[1]. Yang W, et, al. Non-classical ferroptosis inhibition by a small molecule targeting PHB2. Nat Commun. 2022 Dec 3;13(1):7473.
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