For research use only. Not for therapeutic Use.
YKL-06-062（Cat No.:I017817）is a potent, selective small-molecule inhibitor of salt-inducible kinases (SIKs), a family of AMPK-related kinases involved in metabolic regulation, inflammation, and cellular signaling. By blocking SIK activity, YKL-06-062 modulates downstream transcriptional programs such as CREB-mediated gene expression, influencing immune responses and metabolic pathways. This compound is widely used to investigate SIK biology in contexts like cancer, inflammation, and metabolic disorders. Its strong potency, selectivity, and cellular activity make YKL-06-062 an important research tool for uncovering therapeutic strategies targeting kinase-dependent disease mechanisms.
| CAS Number | 2172617-16-0 |
| Synonyms | 1-cyclohexyl-3-(2,6-dimethylphenyl)-7-[4-(4-methylpiperazin-1-yl)anilino]-4H-pyrimido[4,5-d]pyrimidin-2-one |
| Molecular Formula | C31H39N7O |
| Purity | ≥95% |
| IUPAC Name | 1-cyclohexyl-3-(2,6-dimethylphenyl)-7-[4-(4-methylpiperazin-1-yl)anilino]-4H-pyrimido[4,5-d]pyrimidin-2-one |
| InChI | InChI=1S/C31H39N7O/c1-22-8-7-9-23(2)28(22)37-21-24-20-32-30(34-29(24)38(31(37)39)27-10-5-4-6-11-27)33-25-12-14-26(15-13-25)36-18-16-35(3)17-19-36/h7-9,12-15,20,27H,4-6,10-11,16-19,21H2,1-3H3,(H,32,33,34) |
| InChIKey | GFXPGVPPWWPDPV-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=CC=C1)C)N2CC3=CN=C(N=C3N(C2=O)C4CCCCC4)NC5=CC=C(C=C5)N6CCN(CC6)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
