YIL781 hydrochloride

• CAT Number: I012025
• CAS Number: 1640226-17-0
• Molecular Formula: C24H29ClFN3O2
• Molecular Weight: 445.96
• Purity: ≥95%
• Synonyms: 6-(4-fluorophenoxy)-2-methyl-3-[[(3S)-1-propan-2-ylpiperidin-3-yl]methyl]quinazolin-4-one;hydrochloride
• InChI: InChI=1S/C24H28FN3O2.ClH/c1-16(2)27-12-4-5-18(14-27)15-28-17(3)26-23-11-10-21(13-22(23)24(28)29)30-20-8-6-19(25)7-9-20;/h6-11,13,16,18H,4-5,12,14-15H2,1-3H3;1H/t18-;/m0./s1
• InChIKey: QQGRMONBDBMLSP-FERBBOLQSA-N
• SMILES: CC1=NC2=C(C=C(C=C2)OC3=CC=C(C=C3)F)C(=O)N1C[C@H]4CCCN(C4)C(C)C.Cl

YIL781 hydrochloride（Cat No.:I012025）is a selective antagonist of the ghrelin receptor (GHSR1a), a G protein–coupled receptor involved in appetite regulation, energy balance, and growth hormone release. By blocking ghrelin-mediated signaling, YIL781 reduces food intake and modulates metabolic processes, making it a useful research compound for studying obesity, metabolic syndrome, and related disorders. The hydrochloride salt enhances solubility and handling for experimental applications. YIL781 hydrochloride is widely applied in endocrinology and neurobiology to probe ghrelin receptor function, appetite control mechanisms, and therapeutic strategies targeting energy metabolism.