yGsy2p-IN-H23

• CAT Number: I045468
• CAS Number: 1269190-98-8
• Molecular Formula: C23H27N3O2
• Molecular Weight: 377.48
• Purity: ≥95%
• Synonyms: 2-methoxy-4-[3-[2-(1-methylpyrrolidin-2-yl)ethyl]-5-phenylimidazol-4-yl]phenol
• InChI: InChI=1S/C23H27N3O2/c1-25-13-6-9-19(25)12-14-26-16-24-22(17-7-4-3-5-8-17)23(26)18-10-11-20(27)21(15-18)28-2/h3-5,7-8,10-11,15-16,19,27H,6,9,12-14H2,1-2H3
• InChIKey: YGPHAIXUDLLWHC-UHFFFAOYSA-N
• SMILES: CN1CCCC1CCN2C=NC(=C2C3=CC(=C(C=C3)O)OC)C4=CC=CC=C4

yGsy2p-IN-H23 (Cat No.: I045468) is a selective inhibitor of glycogen synthase 2 from Saccharomyces cerevisiae (yGsy2p), an enzyme responsible for catalyzing the elongation of glycogen chains via α-1,4-glycosidic bond formation. By blocking yGsy2p activity, this compound disrupts glycogen biosynthesis, making it a useful tool for studying carbohydrate metabolism, energy storage, and glycogen regulation in yeast. yGsy2p-IN-H23 is applied in biochemical research to explore glycogen-related metabolic pathways and can aid in developing antifungal strategies targeting fungal-specific glycogen synthase isoforms without affecting mammalian counterparts.

Reference

[1]. Buyun Tang, et al. Discovery and Development of Small-Molecule Inhibitors of Glycogen Synthase. J Med Chem. 2020 Apr 9;63(7):3538-3551.
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