YG1702

• CAT Number: I040554
• CAS Number: 724737-08-0
• Molecular Formula: C23H30N2O7S
• Molecular Weight: 478.56
• Purity: ≥95%
• Synonyms: 3-O-(2-methoxyethyl) 5-O-(2-propan-2-ylsulfanylethyl) 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• InChI: InChI=1S/C23H30N2O7S/c1-14(2)33-13-12-32-23(27)20-16(4)24-15(3)19(22(26)31-11-10-30-5)21(20)17-8-6-7-9-18(17)25(28)29/h6-9,14,21,24H,10-13H2,1-5H3
• InChIKey: WBMJXHUWKGEKBB-UHFFFAOYSA-N
• SMILES: CC1=C(C(C(=C(N1)C)C(=O)OCCSC(C)C)C2=CC=CC=C2[N+](=O)[O-])C(=O)OCCOC

YG1702 (Cat No.: I040554) is an investigational, orally active small-molecule TLR8 (Toll-like receptor 8) agonist, developed to stimulate innate immune responses for therapeutic applications in infectious diseases and cancer immunotherapy. By activating TLR8, YG1702 promotes the production of pro-inflammatory cytokines and enhances the activity of dendritic cells and T cells, thereby strengthening host immune defenses. It is being explored in preclinical and early clinical studies as a potential adjuvant or standalone immunotherapeutic agent aimed at boosting immune surveillance and antitumor immunity.

Reference

[1]. Guo YF, et al. Inhibition of the ALDH18A1-MYCN positive feedback loop attenuates MYCN-amplified neuroblastoma growth. Sci Transl Med. 2020 Feb 19;12(531):eaax8694.
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