YB-0158

• CAT Number: I044493
• CAS Number: 1144043-83-3
• Molecular Formula: C32H32N7Na2O7P
• Molecular Weight: 703.59
• Purity: ≥95%
• Synonyms: disodium;[4-[[(6S,9aS)-1-(benzylcarbamoyl)-8-(1H-indazol-7-ylmethyl)-4,7-dioxo-2-prop-2-enyl-3,6,9,9a-tetrahydropyrazino[2,1-c][1,2,4]triazin-6-yl]methyl]phenyl] phosphate
• InChI: InChI=1S/C32H34N7O7P.2Na/c1-2-15-37-21-29(40)38-27(16-22-11-13-26(14-12-22)46-47(43,44)45)31(41)36(19-25-10-6-9-24-18-34-35-30(24)25)20-28(38)39(37)32(42)33-17-23-7-4-3-5-8-23;;/h2-14,18,27-28H,1,15-17,19-21H2,(H,33,42)(H,34,35)(H2,43,44,45);;/q;2*+1/p-2/t27-,28-;;/m0../s1
• InChIKey: BUCIVAHDHKFRLG-QLBXQKMFSA-L
• SMILES: C=CCN1CC(=O)N2[C@@H](N1C(=O)NCC3=CC=CC=C3)CN(C(=O)[C@@H]2CC4=CC=C(C=C4)OP(=O)([O-])[O-])CC5=CC=CC6=C5NN=C6.[Na+].[Na+]

YB-0158（Cat No.:I044493）is a synthetic small-molecule compound designed to target cancer stem cell pathways by modulating epigenetic regulators, particularly focusing on protein methylation and acetylation dynamics. It exhibits potent anti-tumor activity by disrupting transcriptional networks that sustain cancer stemness, proliferation, and survival. YB-0158 has shown efficacy in preclinical models of aggressive cancers, including colorectal and breast cancer, by impairing tumor-initiating cell populations and enhancing sensitivity to chemotherapeutics. Its mechanism involves altering chromatin structure and gene expression, making it a promising candidate for combination therapies in treatment-resistant and metastatic cancers.