XZ426

• CAT Number: I042506
• CAS Number: 1638504-52-5
• Molecular Formula: C22H24F2N4O4
• Molecular Weight: 446.45
• Purity: ≥95%
• Synonyms: 4-amino-N-[(2,4-difluorophenyl)methyl]-1-hydroxy-6-(6-hydroxyhexyl)-2-oxo-1,8-naphthyridine-3-carboxamide
• InChI: InChI=1S/C22H24F2N4O4/c23-15-7-6-14(17(24)10-15)12-27-21(30)18-19(25)16-9-13(5-3-1-2-4-8-29)11-26-20(16)28(32)22(18)31/h6-7,9-11,29,32H,1-5,8,12,25H2,(H,27,30)
• InChIKey: YZHRHLDMVJVVOL-UHFFFAOYSA-N
• SMILES: C1=CC(=C(C=C1F)F)CNC(=O)C2=C(C3=C(N=CC(=C3)CCCCCCO)N(C2=O)O)N

XZ426 (Cat No.:I042506) is a small-molecule inhibitor designed to target and inhibit HDAC6 (histone deacetylase 6), an enzyme involved in deacetylating non-histone proteins such as α-tubulin and HSP90. HDAC6 plays a critical role in cell motility, protein degradation, and stress response. By selectively inhibiting HDAC6, XZ426 has shown potential in preclinical studies for treating neurodegenerative diseases, cancer, and inflammatory conditions. Its selectivity may reduce side effects associated with pan-HDAC inhibitors, making XZ426 a promising candidate for targeted epigenetic therapy.

Reference

[1]. Dario Oliveira Passos, et al. Structural basis for strand-transfer inhibitor binding to HIV intasomes. Science. 2020 Feb 14;367(6479):810-814.
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