For research use only. Not for therapeutic Use.
XY028‑140（Cat No.:I044696）is a novel, small-molecule inhibitor targeting the kinase activity of PLK1 (Polo‑like kinase 1), a key regulator of mitosis and cell cycle progression. By binding the ATP‑competent pocket, it effectively blocks PLK1 phosphorylation activity, leading to mitotic arrest and apoptosis in rapidly proliferating cancer cells. XY028‑140 shows high selectivity over other kinases, minimizing off‑target toxicities. In preclinical models, it has demonstrated potent antitumor activity in breast and lung cancer xenografts. With favorable pharmacokinetics and tolerability, XY028‑140 is positioned as a promising candidate for targeted cancer therapy.
| CAS Number | 2229974-83-6 |
| Synonyms | 4-[[2-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]-2-oxoethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| Molecular Formula | C39H40N10O7 |
| Purity | ≥95% |
| IUPAC Name | 4-[[2-[4-[6-[(6-acetyl-8-cyclopentyl-5-methyl-7-oxopyrido[2,3-d]pyrimidin-2-yl)amino]pyridin-3-yl]piperazin-1-yl]-2-oxoethyl]amino]-2-(2,6-dioxopiperidin-3-yl)isoindole-1,3-dione |
| InChI | InChI=1S/C39H40N10O7/c1-21-26-19-42-39(45-34(26)48(23-6-3-4-7-23)37(55)32(21)22(2)50)43-29-12-10-24(18-41-29)46-14-16-47(17-15-46)31(52)20-40-27-9-5-8-25-33(27)38(56)49(36(25)54)28-11-13-30(51)44-35(28)53/h5,8-10,12,18-19,23,28,40H,3-4,6-7,11,13-17,20H2,1-2H3,(H,44,51,53)(H,41,42,43,45) |
| InChIKey | IWFNIKIERKCKFZ-UHFFFAOYSA-N |
| SMILES | CC1=C(C(=O)N(C2=NC(=NC=C12)NC3=NC=C(C=C3)N4CCN(CC4)C(=O)CNC5=CC=CC6=C5C(=O)N(C6=O)C7CCC(=O)NC7=O)C8CCCC8)C(=O)C |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
