For research use only. Not for therapeutic Use.
XT2（Cat No.:I043980）is a novel, selective small-molecule inhibitor designed to target the T cell immunoglobulin and mucin-domain containing-3 (TIM-3) receptor, an immune checkpoint protein involved in regulating immune responses. TIM-3 is implicated in immune evasion by tumors and autoimmune diseases, as its activation suppresses T cell activity. By inhibiting TIM-3, XT2 aims to enhance T cell responses against tumors and promote immune activation. XT2 is being investigated for its potential to boost anti-tumor immunity, making it a promising candidate for cancer immunotherapy and autoimmune disease treatment.
| CAS Number | 2582816-37-1 |
| Synonyms | (2R)-4-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol |
| Molecular Formula | C19H14FN5OS |
| Purity | ≥95% |
| IUPAC Name | (2R)-4-[3-(2-amino-5H-pyrrolo[3,2-d]pyrimidin-7-yl)-4-fluorophenyl]-2-(1,3-thiazol-2-yl)but-3-yn-2-ol |
| InChI | InChI=1S/C19H14FN5OS/c1-19(26,17-22-6-7-27-17)5-4-11-2-3-14(20)12(8-11)13-9-23-15-10-24-18(21)25-16(13)15/h2-3,6-10,23,26H,1H3,(H2,21,24,25)/t19-/m1/s1 |
| InChIKey | NFAPIBSJICIXGB-LJQANCHMSA-N |
| SMILES | C[C@@](C#CC1=CC(=C(C=C1)F)C2=CNC3=CN=C(N=C23)N)(C4=NC=CS4)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
