For research use only. Not for therapeutic Use.
XPW1(CAT: I040605) is a potent and selective inhibitor of CDK9, a cyclin-dependent kinase involved in transcriptional regulation and cell cycle control. Designed to target transcriptional addiction in cancer, XPW1 effectively suppresses tumor growth by inhibiting DNA repair gene expression, particularly in clear cell renal cell carcinoma (ccRCC). With a molecular weight of 656.19 g/mol and high purity (≥99%), XPW1 exhibits strong bioactivity and low toxicity in preclinical models. It is highly soluble in DMSO and ideal for in vitro and in vivo studies. XPW1 is a valuable tool in oncology research focused on transcriptional control and therapeutic intervention.
| CAS Number | 2700286-66-2 |
| Synonyms | N-[4-[[5-chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclohexyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide |
| Molecular Formula | C36H39ClFN7O2 |
| Purity | ≥95% |
| IUPAC Name | N-[4-[[5-chloro-4-[6-[(3-fluorophenyl)methylamino]pyridin-2-yl]pyridin-2-yl]amino]cyclohexyl]-4-[[(E)-4-(dimethylamino)but-2-enoyl]amino]benzamide |
| InChI | InChI=1S/C36H39ClFN7O2/c1-45(2)19-5-10-35(46)42-28-13-11-25(12-14-28)36(47)43-29-17-15-27(16-18-29)41-34-21-30(31(37)23-40-34)32-8-4-9-33(44-32)39-22-24-6-3-7-26(38)20-24/h3-14,20-21,23,27,29H,15-19,22H2,1-2H3,(H,39,44)(H,40,41)(H,42,46)(H,43,47)/b10-5+ |
| InChIKey | DCNDHFXVQIDEQS-BJMVGYQFSA-N |
| SMILES | CN(C)CC=CC(=O)NC1=CC=C(C=C1)C(=O)NC2CCC(CC2)NC3=NC=C(C(=C3)C4=NC(=CC=C4)NCC5=CC(=CC=C5)F)Cl |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
