For research use only. Not for therapeutic Use.
XPC-6444（Cat No.:I017825）is a potent, selective inhibitor of phosphoinositide 3-kinase gamma (PI3Kγ), an isoform implicated in immune cell signaling, inflammation, and cancer progression. By blocking PI3Kγ activity, it disrupts downstream pathways such as AKT and mTOR, reducing immune-suppressive myeloid cell function in the tumor microenvironment. This positions XPC-6444 as a promising candidate in oncology research, particularly in combination immunotherapy. It is also explored in inflammatory disease models to assess its role in modulating immune responses. XPC-6444 serves as a valuable tool for studying PI3Kγ biology and therapeutic potential.
| CAS Number | 2230144-21-3 |
| Synonyms | 4-[[2-[[tert-butyl(methyl)amino]methyl]-6-fluorophenyl]methylamino]-2,6-difluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide |
| Molecular Formula | C22H25F3N4O2S2 |
| Purity | ≥95% |
| IUPAC Name | 4-[[2-[[tert-butyl(methyl)amino]methyl]-6-fluorophenyl]methylamino]-2,6-difluoro-N-(1,3-thiazol-4-yl)benzenesulfonamide |
| InChI | InChI=1S/C22H25F3N4O2S2/c1-22(2,3)29(4)11-14-6-5-7-17(23)16(14)10-26-15-8-18(24)21(19(25)9-15)33(30,31)28-20-12-32-13-27-20/h5-9,12-13,26,28H,10-11H2,1-4H3 |
| InChIKey | VOJFVKGTRNXOTJ-UHFFFAOYSA-N |
| SMILES | CC(C)(C)N(C)CC1=C(C(=CC=C1)F)CNC2=CC(=C(C(=C2)F)S(=O)(=O)NC3=CSC=N3)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
