XmAb 5592

• CAT Number: I042216
• CAS Number: 1221901-33-2
• Purity: ≥95%

XmAb 5592 (CatNo.: I042216) is an investigational monoclonal antibody engineered using Xencor’s XmAb® technology platform to enhance immune activation against cancer. It targets the CD40 receptor, a key co-stimulatory molecule on antigen-presenting cells, to stimulate both innate and adaptive immune responses. XmAb 5592 is designed as an agonist to promote T-cell activation and improve anti-tumor immunity. Its Fc domain modifications enhance binding to Fcγ receptors, increasing its potency. Currently in preclinical or early clinical development, it holds promise for combination immunotherapy strategies.

Reference

[1]. Tai YT, et, al. Potent in vitro and in vivo activity of an Fc-engineered humanized anti-HM1.24 antibody against multiple myeloma via augmented effector function. Blood. 2012 Mar 1;119(9):2074-82.
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