For research use only. Not for therapeutic Use.
XL177A（Cat No.:I038434）is a highly selective, covalent inhibitor of USP7 (ubiquitin-specific protease 7), a deubiquitinating enzyme involved in regulating the stability of proteins such as MDM2 and p53. By irreversibly binding to USP7, XL177A promotes the degradation of oncogenic substrates and stabilizes tumor suppressor proteins, leading to enhanced apoptosis and growth inhibition in cancer cells. It has demonstrated potent antitumor activity in preclinical models, particularly in hematologic malignancies. XL177A is a valuable tool for studying ubiquitin signaling and supports the development of targeted therapies involving deubiquitinase inhibition in cancer research.
| CAS Number | 2417089-74-6 |
| Synonyms | N-[(4S)-4-benzyl-5-[4-hydroxy-4-[[7-[3-(4-methylpiperazin-1-yl)propanoylamino]-4-oxoquinazolin-3-yl]methyl]piperidin-1-yl]-5-oxopentyl]-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide |
| Molecular Formula | C48H57ClN8O5 |
| Purity | ≥95% |
| IUPAC Name | N-[(4S)-4-benzyl-5-[4-hydroxy-4-[[7-[3-(4-methylpiperazin-1-yl)propanoylamino]-4-oxoquinazolin-3-yl]methyl]piperidin-1-yl]-5-oxopentyl]-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide |
| InChI | InChI=1S/C48H57ClN8O5/c1-54-24-26-55(27-25-54)21-17-43(58)52-36-14-16-39-41(30-36)51-32-57(47(39)61)31-48(62)18-22-56(23-19-48)46(60)35(28-33-8-3-2-4-9-33)10-7-20-50-45(59)34-13-15-38-42(29-34)53-40-12-6-5-11-37(40)44(38)49/h2-4,8-9,13-16,29-30,32,35,62H,5-7,10-12,17-28,31H2,1H3,(H,50,59)(H,52,58)/t35-/m0/s1 |
| InChIKey | UYJWYMWIVMCGQZ-DHUJRADRSA-N |
| SMILES | CN1CCN(CC1)CCC(=O)NC2=CC3=C(C=C2)C(=O)N(C=N3)CC4(CCN(CC4)C(=O)[C@@H](CCCNC(=O)C5=CC6=C(C=C5)C(=C7CCCCC7=N6)Cl)CC8=CC=CC=C8)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
