X-Phos

• CAT Number: L040701
• CAS Number: 564483-18-7
• Molecular Formula: C33H49P
• Molecular Weight: 476.70
• Purity: ≥95%
• IUPAC Name: dicyclohexyl-[2-[2,4,6-tri(propan-2-yl)phenyl]phenyl]phosphane
• InChI: InChI=1S/C33H49P/c1-23(2)26-21-30(24(3)4)33(31(22-26)25(5)6)29-19-13-14-20-32(29)34(27-15-9-7-10-16-27)28-17-11-8-12-18-28/h13-14,19-25,27-28H,7-12,15-18H2,1-6H3
• InChIKey: UGOMMVLRQDMAQQ-UHFFFAOYSA-N
• SMILES: CC(C)C1=CC(=C(C(=C1)C(C)C)C2=CC=CC=C2P(C3CCCCC3)C4CCCCC4)C(C)C

X-Phos (Cat No.:L040701) is a bulky, electron-rich biaryl phosphine ligand widely used in palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura, Buchwald–Hartwig, and Stille couplings. Its unique structure features a rigid biphenyl backbone with sterically demanding isopropyl groups and a dicyclohexylphosphino moiety, which enhances both stability and catalytic activity. X-Phos promotes fast oxidative addition and stabilizes active Pd(0) species, enabling high efficiency under mild conditions. It is particularly effective with challenging aryl chlorides and sterically hindered substrates, making it a valuable tool in pharmaceutical, agrochemical, and materials synthesis.