WSB1 Degrader 1

• CAT Number: I045280
• CAS Number: 2306039-66-5
• Molecular Formula: C21H22N2O2
• Molecular Weight: 334.41
• Purity: ≥95%
• Synonyms: 5,6-bis(4-methoxy-3-methylphenyl)pyridin-2-amine
• InChI: InChI=1S/C21H22N2O2/c1-13-11-15(5-8-18(13)24-3)17-7-10-20(22)23-21(17)16-6-9-19(25-4)14(2)12-16/h5-12H,1-4H3,(H2,22,23)
• InChIKey: AUHCLHXXUVPUBD-UHFFFAOYSA-N
• SMILES: CC1=C(C=CC(=C1)C2=C(N=C(C=C2)N)C3=CC(=C(C=C3)OC)C)OC

WSB1 Degrader 1（Cat No.:I045280）is a potent, orally active small-molecule degrader targeting WSB1 (WD repeat and SOCS box-containing 1), a protein implicated in cancer metastasis. In vitro, it induces time- and dose-dependent degradation of WSB1 in H1299-WSB1 cells (0.25–2500 nM, 2–24 h), and inhibits migration of KHOS and H460 cancer cells with IC₅₀ values of ~39.1 µM and ~24.5 µM, respectively. Under hypoxia, treatment (5 µM) raises RhoGDI2 levels and suppresses wound healing in wild‑type but not WSB1‑knockout A2780 cells. In vivo, daily oral administration (100 mg/kg for 28 days) effectively inhibits pulmonary metastasis in murine models, with acceptable pharmacokinetics following oral or intraperitoneal dosing.