WRW4

• CAT Number: P000159
• CAS Number: 878557-55-2
• Molecular Formula: C61H65N15O6
• Molecular Weight: 1104.27
• Purity: ≥95%
• Synonyms: (2S)-N-[(2S)-1-[[(2S)-1-[[(2S)-1-[[(2S)-1-amino-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]amino]-3-(1H-indol-3-yl)-1-oxopropan-2-yl]-2-[[(2S)-2-amino-3-(1H-indol-3-yl)propanoyl]amino]-5-(diaminomethylideneamino)pentanamide
• InChI: InChI=1S/C61H65N15O6/c62-44(24-34-29-67-45-17-6-1-12-39(34)45)56(78)72-50(22-11-23-66-61(64)65)57(79)74-53(27-37-32-70-48-20-9-4-15-42(37)48)59(81)76-54(28-38-33-71-49-21-10-5-16-43(38)49)60(82)75-52(26-36-31-69-47-19-8-3-14-41(36)47)58(80)73-51(55(63)77)25-35-30-68-46-18-7-2-13-40(35)46/h1-10,12-21,29-33,44,50-54,67-71H,11,22-28,62H2,(H2,63,77)(H,72,78)(H,73,80)(H,74,79)(H,75,82)(H,76,81)(H4,64,65,66)/t44-,50-,51-,52-,53-,54-/m0/s1
• InChIKey: IRJDOVLLPORVJP-WOAIKHIASA-N
• SMILES: C1=CC=C2C(=C1)C(=CN2)C[C@@H](C(=O)N[C@@H](CCCN=C(N)N)C(=O)N[C@@H](CC3=CNC4=CC=CC=C43)C(=O)N[C@@H](CC5=CNC6=CC=CC=C65)C(=O)N[C@@H](CC7=CNC8=CC=CC=C87)C(=O)N[C@@H](CC9=CNC1=CC=CC=C19)C(=O)N)N

WRW4（Cat No.:P000159）is a synthetic hexapeptide (Trp-Arg-Trp-Trp-Trp-Trp) that functions as a potent and selective antagonist of the formyl peptide receptor-like 2 (FPRL2/FPR2), a G-protein–coupled receptor implicated in inflammation and immune regulation. By blocking FPR2 signaling, WRW4 inhibits neutrophil migration and pro-inflammatory responses, making it a valuable pharmacological tool in immunology research. Its high specificity enables detailed study of FPR2-mediated pathways in innate immunity, host defense, and inflammatory resolution. WRW4 is frequently applied in models of chronic inflammation, infection, and autoimmune disease to investigate therapeutic targeting strategies.