For research use only. Not for therapeutic Use.
WNK1-IN-1 (Cat No.: I042607) is a selective small-molecule inhibitor targeting WNK1 (With No Lysine [K] 1) kinase, a key regulator of ion transport and blood pressure. WNK1 plays a critical role in maintaining electrolyte balance by modulating the activity of ion channels and transporters, such as the sodium-chloride co-transporter (NCC). By inhibiting WNK1, WNK1-IN-1 has potential therapeutic applications in treating hypertension and related cardiovascular disorders. It is also used in research to study renal physiology and signal transduction involving WNK kinases.
| CAS Number | 324022-39-1 |
| Synonyms | 4-[bromo(dichloro)methyl]sulfonyl-N-cyclohexyl-2-nitroaniline |
| Molecular Formula | C13H15BrCl2N2O4S |
| Purity | ≥95% |
| InChI | InChI=1S/C13H15BrCl2N2O4S/c14-13(15,16)23(21,22)10-6-7-11(12(8-10)18(19)20)17-9-4-2-1-3-5-9/h6-9,17H,1-5H2 |
| InChIKey | REBZZEDLLSTDTN-UHFFFAOYSA-N |
| SMILES | C1CCC(CC1)NC2=C(C=C(C=C2)S(=O)(=O)C(Cl)(Cl)Br)[N+](=O)[O-] |
| Reference | [1]. Rodriguez M, et al. Synthesis and Structural Characterization of Novel Trihalo-sulfone Inhibitors of WNK1. ACS Med Chem Lett. 2022 Sep 23;13(10):1678-1684. |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
