Wilfortrine

• CAT Number: I044943
• CAS Number: 37239-48-8
• Molecular Formula: C41H47NO20
• Molecular Weight: 873.81
• Purity: ≥95%
• Synonyms: [(1S,3R,18S,19R,20R,21R,22S,23R,24S,25R)-20,22,23,25-tetraacetyloxy-21-(acetyloxymethyl)-15,26-dihydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.01,21.03,24.07,12]hexacosa-7(12),8,10-trien-19-yl] furan-3-carboxylate
• IUPAC Name: [(1S,3R,18S,19R,20R,21R,22S,23R,24R,25R,26S)-20,22,23,25-tetraacetyloxy-21-(acetyloxymethyl)-15,26-dihydroxy-3,15,26-trimethyl-6,16-dioxo-2,5,17-trioxa-11-azapentacyclo[16.7.1.01,21.03,24.07,12]hexacosa-7(12),8,10-trien-19-yl] furan-2-carboxylate
• InChI: InChI=1S/C41H47NO20/c1-19(43)54-18-40-32(58-22(4)46)28(56-20(2)44)27-30(57-21(3)45)41(40)39(8,52)31(29(33(40)59-23(5)47)60-35(49)26-12-10-16-53-26)61-36(50)37(6,51)14-13-25-24(11-9-15-42-25)34(48)55-17-38(27,7)62-41/h9-12,15-16,27-33,51-52H,13-14,17-18H2,1-8H3/t27-,28-,29+,30-,31+,32-,33+,37?,38+,39+,40-,41+/m1/s1
• InChIKey: BGZMJSHSQVGXTE-MIFXYLFUSA-N
• SMILES: CC(=O)OC[C@]12[C@@H]([C@@H]([C@@H]3[C@H]([C@]14[C@@]([C@H]([C@@H]([C@@H]2OC(=O)C)OC(=O)C5=CC=CO5)OC(=O)C(CCC6=C(C=CC=N6)C(=O)OC[C@@]3(O4)C)(C)O)(C)O)OC(=O)C)OC(=O)C)OC(=O)C

Wilfortrine（Cat No.:I044943）is a bioactive sesquiterpene alkaloid extracted from Tripterygium wilfordii, a traditional Chinese medicinal plant. It exhibits potent immunosuppressive and anti-inflammatory properties, contributing to its potential in treating autoimmune conditions such as rheumatoid arthritis and systemic lupus erythematosus. Wilfortrine modulates immune responses by inhibiting T-cell activation and cytokine production. Its molecular structure includes a diterpenoid skeleton fused with nitrogen-containing moieties, which underpins its pharmacological activity. Ongoing research aims to improve its bioavailability and reduce toxicity, making it a promising lead compound for immunomodulatory drug development.