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WHI-P180

WHI-P180

  • CAT Number: I002628
  • CAS Number: 211555-08-7
  • Molecular Formula: C16H15N3O3
  • Molecular Weight: 297.31
  • Purity: ≥95%
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WHI-P180（Cat No.:I002628） is an inhibitor of multiple kinases with IC50 values of 4.5 nM and 66 nM for RET (c-RET) and KDR, respectively. WHI-P180 is also an active inhibitor of IgE-mediated mast cell responses.

Catalog Number I002628
CAS Number 211555-08-7
Molecular Formula

C16H15N3O3

Purity 95%
Target Cyclin-Dependent Kinases
Solubility 10 mM in DMSO
Storage Store at -20C
IC50 1 uM (Cdk2); 4 uM (EGFR)
IUPAC Name 3-[(6,7-dimethoxyquinazolin-4-yl)amino]phenol
InChI InChI=1S/C16H15N3O3/c1-21-14-7-12-13(8-15(14)22-2)17-9-18-16(12)19-10-4-3-5-11(20)6-10/h3-9,20H,1-2H3,(H,17,18,19)
InChIKey BNDYIYYKEIXHNK-UHFFFAOYSA-N
SMILES COC1=C(C=C2C(=C1)C(=NC=N2)NC3=CC(=CC=C3)O)OC
Reference

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<br>[1]. An R, et al. Cellular phototoxicity evoked through the inhibition of human ABC transporter ABCG2 by cyclin-dependent kinase inhibitors in vitro. Pharm Res. 2009 Feb;26(2):449-58.

<br>[2]. Chen CL, et al. Pharmacokinetics and biologic activity of the novel mast cell inhibitor, 4-(3-hydroxyphenyl)-amino-6,7-dimethoxyquinazoline in mice. Pharm Res. 1999 Jan;16(1):117-22.

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