WH-4-025

• CAT Number: I044650
• CAS Number: 1876463-35-2
• Molecular Formula: C39H38F3N7O5
• Molecular Weight: 741.76
• Purity: ≥95%
• Synonyms: [2-methyl-5-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl] N-(2,4-dimethoxyphenyl)-N-[2-[4-(4-methylpiperazin-1-yl)anilino]pyrimidin-4-yl]carbamate
• InChI: InChI=1S/C39H38F3N7O5/c1-25-8-9-26(36(50)44-29-7-5-6-27(23-29)39(40,41)42)22-33(25)54-38(51)49(32-15-14-31(52-3)24-34(32)53-4)35-16-17-43-37(46-35)45-28-10-12-30(13-11-28)48-20-18-47(2)19-21-48/h5-17,22-24H,18-21H2,1-4H3,(H,44,50)(H,43,45,46)
• InChIKey: MWWDOHSKUDECFQ-UHFFFAOYSA-N
• SMILES: CC1=C(C=C(C=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F)OC(=O)N(C3=C(C=C(C=C3)OC)OC)C4=NC(=NC=C4)NC5=CC=C(C=C5)N6CCN(CC6)C

WH-4-025（Cat No.:I044650）is a potent and selective small-molecule inhibitor of salt-inducible kinases (SIKs), particularly SIK1, SIK2, and SIK3. It modulates transcriptional and inflammatory signaling pathways by inhibiting SIK-mediated phosphorylation events, such as those affecting CREB-regulated transcription coactivators (CRTCs). WH-4-025 is widely used in cellular and in vivo studies exploring metabolic regulation, immune modulation, and potential treatments for inflammatory diseases and depression. With high purity and good cell permeability, it is supplied as a solid and is soluble in DMSO. WH-4-025 is a valuable tool for investigating SIK-related biological processes and therapeutic targets.