Wedelolactone

• CAT Number: R006650
• CAS Number: 524-12-9
• Molecular Formula: C16H10O7
• Molecular Weight: 314.249
• Purity: ≥95%
• Target: IκB/IKK
• IUPAC Name: 1,8,9-trihydroxy-3-methoxy-[1]benzofuro[3,2-c]chromen-6-one
• InChI: InChI=1S/C16H10O7/c1-21-6-2-10(19)14-12(3-6)23-16(20)13-7-4-8(17)9(18)5-11(7)22-15(13)14/h2-5,17-19H,1H3
• InChIKey: XQDCKJKKMFWXGB-UHFFFAOYSA-N
• SMILES: COC1=CC(=C2C(=C1)OC(=O)C3=C2OC4=CC(=C(C=C43)O)O)O

Wedelolactone (CAS 524-12-9) is an Irreversible inhibitor of IKKα and β kinase activity (IC50 < 10 μM). It inhibits NF-κB-mediated gene transcription in cells by blocking the phosphorylation and degradation of IκBα. Wedelolactone has no effects on p38 MAP kinase or Akt.

Reference

1.Kobori, M., et al. 2004. Cell Death Differ. 11, 123.
2.Li, C.C., et al. 2003. J. Org. Chem. 68, 8500.
3.Mors, W.B., et al. 1989. Toxicon 27, 1003.
4.Wagner, H., and Fessler, B. 1986. Planta Med. 5, 374.