For research use only. Not for therapeutic Use.
WAY-606376(CAT: I040594) is a potent and selective small-molecule inhibitor of O-GlcNAcase (OGA), an enzyme responsible for removing O-GlcNAc modifications from intracellular proteins. By inhibiting OGA, WAY-606376 increases protein O-GlcNAcylation, a dynamic post-translational modification implicated in key cellular processes including transcription, signal transduction, and stress response. This compound is valuable for investigating the role of O-GlcNAc cycling in neurodegenerative diseases, cancer, and metabolic disorders. WAY-606376 offers excellent cell permeability and target specificity, making it a reliable chemical probe for mechanistic studies of O-GlcNAc-related pathways and epigenetic regulation in both in vitro and in vivo models.
| CAS Number | 522639-94-7 |
| Synonyms | 2-(furan-2-yl)-N-(4-methyl-1,3-thiazol-2-yl)quinoline-4-carboxamide |
| Molecular Formula | C18H13N3O2S |
| Purity | ≥95% |
| IUPAC Name | 2-(furan-2-yl)-N-(4-methyl-1,3-thiazol-2-yl)quinoline-4-carboxamide |
| InChI | InChI=1S/C18H13N3O2S/c1-11-10-24-18(19-11)21-17(22)13-9-15(16-7-4-8-23-16)20-14-6-3-2-5-12(13)14/h2-10H,1H3,(H,19,21,22) |
| InChIKey | FJNSTSOBVHFVEK-UHFFFAOYSA-N |
| SMILES | CC1=CSC(=N1)NC(=O)C2=CC(=NC3=CC=CC=C32)C4=CC=CO4 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
