WAY-100135 dihydrochloride

• CAT Number: I045549
• CAS Number: 149055-79-8
• Molecular Formula: C24H35Cl2N3O2
• Molecular Weight: 468.46
• Purity: ≥95%
• Synonyms: N-tert-butyl-3-[4-(2-methoxyphenyl)piperazin-1-yl]-2-phenylpropanamide;dihydrochloride
• InChI: InChI=1S/C24H33N3O2.2ClH/c1-24(2,3)25-23(28)20(19-10-6-5-7-11-19)18-26-14-16-27(17-15-26)21-12-8-9-13-22(21)29-4;;/h5-13,20H,14-18H2,1-4H3,(H,25,28);2*1H
• InChIKey: VJGZNBYDSDEOED-UHFFFAOYSA-N
• SMILES: CC(C)(C)NC(=O)C(CN1CCN(CC1)C2=CC=CC=C2OC)C3=CC=CC=C3.Cl.Cl

WAY-100135 dihydrochloride (Cat No.: I045549) is a selective 5-HT1A receptor antagonist widely used in neuropharmacology and behavioral neuroscience research. By blocking serotonin 5-HT1A autoreceptors and postsynaptic receptors, it enhances serotonergic neurotransmission and allows precise study of 5-HT1A-mediated signaling. This compound has been employed to investigate mood regulation, anxiety, depression, and schizophrenia, as well as the pharmacological effects of serotonergic drugs. The dihydrochloride salt improves solubility and stability, making it suitable for laboratory applications. It remains a valuable tool for serotonin receptor research.

Reference

[1]. Fletcher A, et, al. WAY100135: a novel, selective antagonist at presynaptic and postsynaptic 5-HT1A receptors. Eur J Pharmacol. 1993 Jun 24;237(2-3):283-91.
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[2]. Han L, et, al. 5-HT 1A receptor-mediated attenuation of synaptic transmission in rat medial vestibular nucleus impacts on vestibular-related motor function. J Physiol. 2021 Jan;599(1):253-267.
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