For research use only. Not for therapeutic Use.
W1131 TFA(CAT: I040301) is a potent inhibitor of STAT3 signaling that induces ferroptosis and exhibits strong anticancer efficacy. It significantly suppresses tumor progression in gastric cancer models, including subcutaneous xenografts, organoids, and patient-derived xenografts (PDX). W1131 enhances sensitivity to 5-fluorouracil (5-FU, HY-90006), effectively overcoming chemoresistance. Mechanistically, it regulates multiple cellular pathways, including the IL6-JAK-STAT3 axis, ferroptosis, cell cycle progression, DNA damage response, and oxidative phosphorylation. As a trifluoroacetate salt, W1131 TFA offers improved solubility and stability for in vivo and in vitro applications. This compound is a valuable research tool for exploring targeted therapies in gastric and other STAT3-driven cancers.
| Synonyms | 5-nitro-N-[4-[7-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]furan-2-carboxamide;2,2,2-trifluoroacetic acid |
| Molecular Formula | C25H20F3N5O6 |
| Purity | ≥95% |
| IUPAC Name | 5-nitro-N-[4-[7-(1,2,3,6-tetrahydropyridin-4-yl)imidazo[1,2-a]pyridin-3-yl]phenyl]furan-2-carboxamide;2,2,2-trifluoroacetic acid |
| InChI | InChI=1S/C23H19N5O4.C2HF3O2/c29-23(20-5-6-22(32-20)28(30)31)26-18-3-1-16(2-4-18)19-14-25-21-13-17(9-12-27(19)21)15-7-10-24-11-8-15;3-2(4,5)1(6)7/h1-7,9,12-14,24H,8,10-11H2,(H,26,29);(H,6,7) |
| InChIKey | CTRNPGALIMEDJQ-UHFFFAOYSA-N |
| SMILES | C1CNCC=C1C2=CC3=NC=C(N3C=C2)C4=CC=C(C=C4)NC(=O)C5=CC=C(O5)[N+](=O)[O-].C(=O)(C(F)(F)F)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
