For research use only. Not for therapeutic Use.
VX-150（Cat No.:I044416）is a selective, orally bioavailable inhibitor of the voltage-gated sodium channel NaV1.8, which plays a key role in pain signal transmission in peripheral sensory neurons. By blocking NaV1.8, VX-150 reduces neuronal excitability and attenuates pain perception without affecting central nervous system function. It has demonstrated efficacy in preclinical and clinical studies for various pain conditions, including neuropathic and inflammatory pain. VX-150 represents a promising non-opioid analgesic candidate, offering a targeted approach to pain management with potentially fewer side effects compared to traditional pain therapies.
| CAS Number | 1793080-72-4 |
| Synonyms | [4-[[2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzoyl]amino]-2-oxopyridin-1-yl]methyl dihydrogen phosphate |
| Molecular Formula | C21H17F4N2O7P |
| Purity | ≥95% |
| IUPAC Name | [4-[[2-(4-fluoro-2-methylphenoxy)-4-(trifluoromethyl)benzoyl]amino]-2-oxopyridin-1-yl]methyl dihydrogen phosphate |
| InChI | InChI=1S/C21H17F4N2O7P/c1-12-8-14(22)3-5-17(12)34-18-9-13(21(23,24)25)2-4-16(18)20(29)26-15-6-7-27(19(28)10-15)11-33-35(30,31)32/h2-10H,11H2,1H3,(H,26,29)(H2,30,31,32) |
| InChIKey | SQDQNNKQTHOQHO-UHFFFAOYSA-N |
| SMILES | CC1=C(C=CC(=C1)F)OC2=C(C=CC(=C2)C(F)(F)F)C(=O)NC3=CC(=O)N(C=C3)COP(=O)(O)O |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
