VU6036720 hydrochloride

• CAT Number: I041419
• Molecular Formula: C20H23Cl2FN4O2S
• Molecular Weight: 473.39
• Purity: ≥95%
• Synonyms: 3-chloro-N-[2-[(2S)-4-(2-cyanophenyl)-2-methylpiperazin-1-yl]ethyl]-4-fluorobenzenesulfonamide;hydrochloride
• InChI: InChI=1S/C20H22ClFN4O2S.ClH/c1-15-14-26(20-5-3-2-4-16(20)13-23)11-10-25(15)9-8-24-29(27,28)17-6-7-19(22)18(21)12-17;/h2-7,12,15,24H,8-11,14H2,1H3;1H/t15-;/m0./s1
• InChIKey: ZRUTWJFQZLMEBJ-RSAXXLAASA-N
• SMILES: C[C@H]1CN(CCN1CCNS(=O)(=O)C2=CC(=C(C=C2)F)Cl)C3=CC=CC=C3C#N.Cl

VU6036720 hydrochloride（Cat No.:I041419）is a selective, potent inhibitor of the protein arginine methyltransferase 5 (PRMT5), an enzyme involved in regulating epigenetic processes through the methylation of arginine residues on histones and other proteins. By targeting PRMT5, VU6036720 hydrochloride has demonstrated potential therapeutic effects in various cancers, particularly those driven by abnormal PRMT5 activity. This inhibitor can disrupt key cellular processes like gene expression, cell proliferation, and survival. It shows promise in the treatment of solid tumors and hematological malignancies, contributing to epigenetic-based cancer therapies and immunomodulation strategies.