VU6019650

• CAT Number: I042369
• CAS Number: 2926782-31-0
• Molecular Formula: C18H22FN3O3S2
• Molecular Weight: 411.51
• Purity: ≥95%
• Synonyms: (3R,4S)-1-(2,3-dihydro-1-benzofuran-5-ylsulfonyl)-3-fluoro-4-[(1-methylimidazol-2-yl)sulfanylmethyl]piperidine
• InChI: InChI=1S/C18H22FN3O3S2/c1-21-8-6-20-18(21)26-12-14-4-7-22(11-16(14)19)27(23,24)15-2-3-17-13(10-15)5-9-25-17/h2-3,6,8,10,14,16H,4-5,7,9,11-12H2,1H3/t14-,16+/m1/s1
• InChIKey: MWXZKSDFCSPEBK-ZBFHGGJFSA-N
• SMILES: CN1C=CN=C1SCC2CCN(CC2F)S(=O)(=O)C3=CC4=C(C=C3)OCC4

VU6019650 (Cat No.: I042369) is a selective small-molecule antagonist of the M5 muscarinic acetylcholine receptor (M5 mAChR), one of the five muscarinic receptor subtypes in the central nervous system. It is primarily used in neuroscience research to explore the role of M5 receptors in modulating dopaminergic signaling, addiction, and neuropsychiatric disorders. VU6019650 exhibits high affinity and selectivity, making it a valuable pharmacological tool for dissecting M5 receptor function. Its use may contribute to the development of novel therapies for disorders like schizophrenia and addiction.

Reference

[1]. Garrison AT, et al. Development of VU6019650: A Potent, Highly Selective, and Systemically Active Orthosteric Antagonist of the M5 Muscarinic Acetylcholine Receptor for the Treatment of Opioid Use Disorder. J Med Chem. 2022 Apr 28;65(8):6273-6286.
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[2]. Capstick RA, et al. Discovery of a potent M5 antagonist with improved clearance profile. Part 1: Piperidine amide-based antagonists. Bioorg Med Chem Lett. 2022 Nov 15;76:128988.
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