For research use only. Not for therapeutic Use.
VU6010572 (Cat No.: I038183) is a selective small-molecule antagonist of the muscarinic acetylcholine receptor subtype M4 (M4 mAChR). It was developed as a research tool to study cholinergic signaling in the central nervous system. By blocking M4 receptor activity, VU6010572 helps elucidate the role of muscarinic pathways in regulating dopamine transmission, motor control, and cognition. This compound is particularly valuable in neuropharmacology for investigating therapeutic strategies in disorders such as Parkinson’s disease, schizophrenia, and other neurological conditions linked to cholinergic dysfunction.
| CAS Number | 2126784-39-0 |
| Synonyms | 1-(4-fluorophenyl)-4-[(2S)-2-phenoxypropoxy]pyridin-2-one |
| Molecular Formula | C20H18FNO3 |
| Purity | ≥95% |
| InChI | InChI=1S/C20H18FNO3/c1-15(25-18-5-3-2-4-6-18)14-24-19-11-12-22(20(23)13-19)17-9-7-16(21)8-10-17/h2-13,15H,14H2,1H3/t15-/m0/s1 |
| InChIKey | AUMJXOXUSGIUCB-HNNXBMFYSA-N |
| SMILES | CC(COC1=CC(=O)N(C=C1)C2=CC=C(C=C2)F)OC3=CC=CC=C3 |
| Reference | [1]. Engers JL, et al. Design and Synthesis of N-Aryl Phenoxyethoxy Pyridinones as Highly Selective and CNS Penetrant mGlu3 NAMs. ACS Med Chem Lett. 2017;8(9):925-930. Published 2017 Aug 15. [2]. Ryan E. Tyler1, et al. The effects of predator odor (TMT) exposure and mGlu3 NAM pretreatment on lasting behavioral and molecular adaptations in the insular cortex and BNST |
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