VU0463271 quarterhydrate

• CAT Number: I045638
• Molecular Formula: C19H18N4OS2.1/4H2O
• Molecular Weight: 387.00
• Purity: ≥95%

VU0463271 quarterhydrate (Cat No.: I045638) is a selective small-molecule inhibitor of the sodium-activated potassium channel Slack (also known as KNa1.1 or Slo2.2). By blocking Slack channel activity, it modulates neuronal excitability and firing patterns, making it a valuable tool for studying ion channel physiology and neurological disorders. The quarterhydrate form ensures enhanced stability for experimental use. Researchers apply VU0463271 quarterhydrate in neuroscience to investigate roles of Slack channels in epilepsy, cognition, and sensory processing. Though not therapeutic, it supports ion channel–targeted drug discovery.

Reference

[1]. Delpire E, et al. Further optimization of the K-Cl cotransporter KCC2 antagonist ML077: development of a highly selective and more potent in vitro probe. Bioorg Med Chem Lett. 2012 Jul 15;22(14):4532-5.
[Content Brief]

[2]. Rui Chen, et al. Functional Coupling of K +-Cl – Cotransporter (KCC) to GABA-Gated Cl – Channels in the Central Nervous System of Drosophila melanogaster Leads to Altered Drug Sensitivities. ACS Chem Neurosci. 2019 Jun 19;10(6):2765-2776.
[Content Brief]