VU0453595

• CAT Number: I038155
• CAS Number: 1432436-13-9
• Molecular Formula: C18H15FN4O
• Molecular Weight: 322.34
• Purity: ≥95%
• Synonyms: 6-[[2-fluoro-4-(1-methylpyrazol-4-yl)phenyl]methyl]-7H-pyrrolo[3,4-b]pyridin-5-one
• InChI: InChI=1S/C18H15FN4O/c1-22-9-14(8-21-22)12-4-5-13(16(19)7-12)10-23-11-17-15(18(23)24)3-2-6-20-17/h2-9H,10-11H2,1H3
• InChIKey: LIZQOZALTSDKFU-UHFFFAOYSA-N
• SMILES: CN1C=C(C=N1)C2=CC(=C(C=C2)CN3CC4=C(C3=O)C=CC=N4)F

VU0453595 (Cat No.: I038155) is a selective, brain-penetrant M1 muscarinic acetylcholine receptor positive allosteric modulator (PAM) developed for neuroscience research. By enhancing M1 receptor activity without directly activating the receptor, it supports studies of cholinergic signaling with improved specificity and reduced off-target effects. VU0453595 has been widely used to investigate cognition, learning, and memory, as well as its potential therapeutic applications in Alzheimer’s disease, schizophrenia, and other cognitive disorders. Its favorable selectivity and potency make it a valuable tool in neuropharmacology and drug discovery.

Reference

[1]. A Ghoshal, et al. Potentiation of M1 Muscarinic Receptor Reverses Plasticity Deficits and Negative and Cognitive Symptoms in a Schizophrenia Mouse Model. Neuropsychopharmacology. 2016 Jan;41(2):598-610.
[Content Brief]

[2]. Sean P Moran, et al. M1-positive allosteric modulators lacking agonist activity provide the optimal profile for enhancing cognition. Neuropsychopharmacology. 2018 Jul;43(8):1763-1771.
[Content Brief]

[3]. Xiaohui Lv, et al. M1 muscarinic activation induces long-lasting increase in intrinsic excitability of striatal projection neurons. Neuropharmacology. 2017 May 15;118:209-222.
[Content Brief]