VU0080241

• CAT Number: I038136
• CAS Number: 393845-24-4
• Molecular Formula: C19H23N5
• Molecular Weight: 321.42
• Purity: ≥95%
• Synonyms: 1-(2,4-dimethylphenyl)-4-(3-methylpiperidin-1-yl)pyrazolo[3,4-d]pyrimidine
• InChI: InChI=1S/C19H23N5/c1-13-6-7-17(15(3)9-13)24-19-16(10-22-24)18(20-12-21-19)23-8-4-5-14(2)11-23/h6-7,9-10,12,14H,4-5,8,11H2,1-3H3
• InChIKey: CLQVVBPDAXJGBV-UHFFFAOYSA-N
• SMILES: CC1CCCN(C1)C2=NC=NC3=C2C=NN3C4=C(C=C(C=C4)C)C

VU0080241 (Cat No.: I038136) is a selective mGluR4 (metabotropic glutamate receptor 4) positive allosteric modulator (PAM) developed for neuroscience research. By enhancing mGluR4 signaling, it modulates glutamatergic neurotransmission without directly activating the receptor, offering improved specificity and reduced side effects compared to traditional agonists. VU0080241 has been employed in studies of Parkinson’s disease, anxiety, and pain, where mGluR4 activity is implicated. Its receptor selectivity and favorable pharmacological profile make it a valuable tool for investigating glutamate signaling, basal ganglia function, and novel CNS therapies.

Reference

[1]. Colleen M Niswender, et al. Positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4): Part I. Discovery of pyrazolo[3,4-d]pyrimidines as novel mGluR4 positive allosteric modulators. Bioorg Med Chem Lett. 2008 Oct 15; 18(20)
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