For research use only. Not for therapeutic Use.
VT107（Cat No.:I038131）is a small-molecule inhibitor designed to target leucine-rich repeat kinase 2 (LRRK2), a kinase implicated in the pathogenesis of Parkinson’s disease. By selectively inhibiting LRRK2 activity, VT107 reduces the phosphorylation of its substrates, thereby modulating pathways involved in neuroinflammation, vesicle trafficking, and neuronal survival. It is used in preclinical research to explore disease-modifying strategies for neurodegeneration associated with LRRK2 mutations. VT107 offers good brain penetration and pharmacokinetic properties, making it a valuable tool for studying the therapeutic potential of LRRK2 inhibition in Parkinson’s disease and related disorders.
| CAS Number | 2417718-63-7 |
| Synonyms | N-[(1S)-1-(6-aminopyridin-2-yl)ethyl]-5-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxamide |
| Molecular Formula | C25H20F3N3O |
| Purity | ≥95% |
| IUPAC Name | N-[(1S)-1-(6-aminopyridin-2-yl)ethyl]-5-[4-(trifluoromethyl)phenyl]naphthalene-2-carboxamide |
| InChI | InChI=1S/C25H20F3N3O/c1-15(22-6-3-7-23(29)31-22)30-24(32)18-10-13-21-17(14-18)4-2-5-20(21)16-8-11-19(12-9-16)25(26,27)28/h2-15H,1H3,(H2,29,31)(H,30,32)/t15-/m0/s1 |
| InChIKey | OBEXKSHQMHIUFP-HNNXBMFYSA-N |
| SMILES | C[C@@H](C1=NC(=CC=C1)N)NC(=O)C2=CC3=C(C=C2)C(=CC=C3)C4=CC=C(C=C4)C(F)(F)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
