VT-103

  • CAT Number: I038128
  • CAS Number: 2290608-13-6
  • Molecular Formula: C18H17F3N4O2S
  • Molecular Weight: 410.42
  • Purity: 98%
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VT-103 (CAT: I038128) is a potent and selective TEAD auto-palmitoylation inhibitor. It shows promising efficacy in inhibiting the proliferation and tumor growth of NF2-deficient mesothelioma. VT-103 is a TEAD1-selective inhibitor, downregulating Hippo pathway target genes. It exhibits good oral bioavailability, long half-lives, and inhibits tumor growth, leading to shrinkage of established tumors in preclinical models of human mesothelioma deficient in functional Merlin. VT-103 holds potential as a therapeutic agent and warrants further investigation as a treatment for NF2-deficient mesothelioma.

Catalog Number I038128
CAS Number 2290608-13-6
Synonyms

VT-103; VT 103; VT103

Molecular Formula

C18H17F3N4O2S

Purity 98
Solubility To be determined
Storage Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).
IUPAC Name N-methyl-3-(1-methyl-1H-imidazol-4-yl)-4-((4-(trifluoromethyl)phenyl)amino)benzenesulfonamide
InChI InChI=1S/C18H17F3N4O2S/c1-22-28(26,27)14-7-8-16(15(9-14)17-10-25(2)11-23-17)24-13-5-3-12(4-6-13)18(19,20)21/h3-11,22,24H,1-2H3
InChIKey LLCVDQHLYHBAHR-UHFFFAOYSA-N
SMILES CN1C=NC(C2=C(NC3=CC=C(C(F)(F)F)C=C3)C=CC(S(=O)(NC)=O)=C2)=C1
Reference

Tang TT, Konradi AW, Feng Y, Peng X, Ma M, Li J, Yu FX, Guan KL, Post L. Small Molecule Inhibitors of TEAD Auto-palmitoylation Selectively Inhibit Proliferation and Tumor Growth of NF2-deficient Mesothelioma. Mol Cancer Ther. 2021 Apr 13:molcanther.0717.2020. doi: 10.1158/1535-7163.MCT-20-0717. Epub ahead of print. PMID: 33850002.

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