VT-103 - CAS 2290608-13-6
VT-103 (CAT: I038128) is a potent and selective TEAD auto-palmitoylation inhibitor. It shows promising efficacy in inhibiting the proliferation and tumor growth of NF2-deficient mesothelioma. VT-103 is a TEAD1-selective inhibitor, downregulating Hippo pathway target genes. It exhibits good oral bioavailability, long half-lives, and inhibits tumor growth, leading to shrinkage of established tumors in preclinical models of human mesothelioma deficient in functional Merlin. VT-103 holds potential as a therapeutic agent and warrants further investigation as a treatment for NF2-deficient mesothelioma.
* For research use only. Not for human or veterinary use.
|Synonyms||VT-103; VT 103; VT103|
|Solubility||To be determined|
|Storage||Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years).|