VRK-IN-1（Cat No.:I044339）is a potent and selective inhibitor of vaccinia-related kinase 1 (VRK1), a serine/threonine kinase involved in cell cycle progression, chromatin remodeling, and DNA damage response. By blocking VRK1 activity, VRK-IN-1 disrupts the phosphorylation of key substrates such as BAF and histone H3, leading to impaired mitosis and cell proliferation. It has shown promising effects in preclinical cancer models, particularly those with VRK1 overexpression. VRK-IN-1 is a valuable research tool for exploring VRK1-related signaling pathways and for developing targeted therapies in oncology and proliferative disorders.