VQW-765

• CAT Number: I002647
• CAS Number: 669770-29-0
• Molecular Formula: C19H22N2O
• Molecular Weight: 294.39
• Purity: ≥95%
• Synonyms: (3R)-3-[6-(4-methylphenyl)pyridin-3-yl]oxy-1-azabicyclo[2.2.2]octane
• InChI: InChI=1S/C19H22N2O/c1-14-2-4-15(5-3-14)18-7-6-17(12-20-18)22-19-13-21-10-8-16(19)9-11-21/h2-7,12,16,19H,8-11,13H2,1H3/t19-/m0/s1
• InChIKey: NPDLTEZXGWRMLQ-IBGZPJMESA-N
• SMILES: CC1=CC=C(C=C1)C2=NC=C(C=C2)OC3CN4CCC3CC4

VQW-765 (Cat No.: I002647) is an investigational small-molecule modulator designed to selectively target GABA-A receptors, particularly subtypes implicated in anxiety and mood regulation. As a partial agonist, it aims to provide anxiolytic and antidepressant effects without the sedation, tolerance, or dependence commonly associated with traditional benzodiazepines. VQW-765 has been explored in clinical trials for conditions such as generalized anxiety disorder and major depressive disorder. Its subtype-selective mechanism offers promise for safer, more precise modulation of GABAergic neurotransmission in psychiatric therapeutics.

Reference

[1]. Feuerbach D, et al. AQW051, a novel, potent and selective α7 nicotinic ACh receptor partial agonist: pharmacological characterization and phase I evaluation. Br J Pharmacol. 2015 Mar;172(5):1292-304.
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