VPC-70619

For research use only. Not for therapeutic Use.

  • CAT Number: I044030
  • CAS Number: 2361742-30-3
  • Molecular Formula: C16H8ClF3N4O
  • Molecular Weight: 364.71
  • Purity: ≥95%
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VPC-70619(Cat No.:I044030)is a selective and potent inhibitor of the N-terminal domain of the androgen receptor (AR-NTD), a critical region for AR transcriptional activity that remains active even in castration-resistant prostate cancer (CRPC). Unlike traditional AR antagonists targeting the ligand-binding domain, VPC-70619 blocks AR-driven gene expression independently of androgen levels, overcoming common resistance mechanisms. This makes it a promising research tool for investigating advanced prostate cancer and AR signaling pathways. VPC-70619 supports the development of next-generation therapies aimed at targeting non-ligand-dependent AR activity in aggressive and treatment-resistant cancers.


CAS Number 2361742-30-3
Synonyms

3-chloro-4-cyano-N’-[4-cyano-2-(trifluoromethyl)phenyl]benzohydrazide

Molecular Formula C16H8ClF3N4O
Purity ≥95%
IUPAC Name 3-chloro-4-cyano-N'-[4-cyano-2-(trifluoromethyl)phenyl]benzohydrazide
InChI InChI=1S/C16H8ClF3N4O/c17-13-6-10(2-3-11(13)8-22)15(25)24-23-14-4-1-9(7-21)5-12(14)16(18,19)20/h1-6,23H,(H,24,25)
InChIKey XTKCWHGATOSBEH-UHFFFAOYSA-N
SMILES C1=CC(=C(C=C1C#N)C(F)(F)F)NNC(=O)C2=CC(=C(C=C2)C#N)Cl
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