Voriconazole N-oxide hydrochloride

• CAT Number: I040329
• Molecular Formula: C16H15ClF3N5O2
• Molecular Weight: 401.77
• Purity: ≥95%
• Synonyms: (2R,3S)-2-(2,4-difluorophenyl)-3-(5-fluoro-1-oxidopyrimidin-1-ium-4-yl)-1-(1,2,4-triazol-1-yl)butan-2-ol;hydrochloride
• InChI: InChI=1S/C16H14F3N5O2.ClH/c1-10(15-14(19)5-24(26)9-21-15)16(25,6-23-8-20-7-22-23)12-3-2-11(17)4-13(12)18;/h2-5,7-10,25H,6H2,1H3;1H/t10-,16+;/m0./s1
• InChIKey: TUFSYNMLEUYAQZ-XVQZZTKGSA-N
• SMILES: CC(C1=NC=[N+](C=C1F)[O-])C(CN2C=NC=N2)(C3=C(C=C(C=C3)F)F)O.Cl

Voriconazole N-oxide (hydrochloride)(CAT: I040329), also known as Voriconazole oxynitride, is the primary circulating metabolite of Voriconazole (HY-76200), a broad-spectrum triazole antifungal agent. Formed via hepatic metabolism primarily by CYP2C19, this compound serves as a critical biomarker for assessing individual metabolic capacity and variability in voriconazole pharmacokinetics. Though it exhibits significantly reduced antifungal activity compared to the parent drug, Voriconazole N-oxide is essential for therapeutic drug monitoring and pharmacogenetic research. Provided as a hydrochloride salt for improved solubility and handling, it is ideal for metabolic profiling, drug interaction studies, and personalized medicine research.