For research use only. Not for therapeutic Use.
VJDT(CAT: I040270) is a small-molecule inhibitor of Triggering Receptor Expressed on Myeloid cells-1 (TREM1), a key mediator of inflammation and immune regulation within the tumor microenvironment. By effectively blocking TREM1 signaling, VJDT suppresses pro-inflammatory pathways and disrupts TREM1-driven tumor-supportive mechanisms. Preclinical studies show that VJDT inhibits tumor growth, making it a promising tool for cancer research, particularly in studies exploring immune modulation and inflammation-associated malignancies. VJDT is ideal for investigating TREM1’s role in tumor progression, immune evasion, and therapeutic resistance, and supports the development of targeted strategies in immuno-oncology.
| Synonyms | 8-benzyl-3,5,9-trioxo-4-phenyl-4,8-diazatricyclo[5.2.2.02,6]undec-10-ene-11-carbonitrile |
| Molecular Formula | C23H17N3O3 |
| Purity | ≥95% |
| IUPAC Name | 8-benzyl-3,5,9-trioxo-4-phenyl-4,8-diazatricyclo[5.2.2.02,6]undec-10-ene-11-carbonitrile |
| InChI | InChI=1S/C23H17N3O3/c24-12-15-11-17-18-19(23(29)26(22(18)28)16-9-5-2-6-10-16)20(15)25(21(17)27)13-14-7-3-1-4-8-14/h1-11,17-20H,13H2 |
| InChIKey | KEFGMZDTNRNDHK-UHFFFAOYSA-N |
| SMILES | C1=CC=C(C=C1)CN2C3C4C(C(C2=O)C=C3C#N)C(=O)N(C4=O)C5=CC=CC=C5 |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
