Vitamin K1

• CAT Number: R011045
• CAS Number: 84-80-0
• Molecular Formula: C31H46O2
• Molecular Weight: 450.70
• Purity: ≥95%
• Synonyms: 2-Methyl-3-[(2E,7R,11R)-3,7,11,15-tetramethyl-2-hexadecenyl]-1,4-naphthalenedione; Konakion; Mephyton; Phytonadione; Phytylmenadione; Phytylmenaquinone; Synthex P; Veda K1; Veta K1; Vitamin K1(20); trans-Phylloquinone; α-Phylloquinone; 2’,3’-trans-V
• Target: Endogenous Metabolite
• Storage: -20°C
• IUPAC Name: 2-methyl-3-[(E,7R,11R)-3,7,11,15-tetramethylhexadec-2-enyl]naphthalene-1,4-dione
• InChI: InChI=1S/C31H46O2/c1-22(2)12-9-13-23(3)14-10-15-24(4)16-11-17-25(5)20-21-27-26(6)30(32)28-18-7-8-19-29(28)31(27)33/h7-8,18-20,22-24H,9-17,21H2,1-6H3/b25-20+/t23-,24-/m1/s1
• InChIKey: MBWXNTAXLNYFJB-NKFFZRIASA-N
• SMILES: CC1=C(C(=O)C2=CC=CC=C2C1=O)C/C=C(\C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C

Vitamin K₁(Cat No.: R011045), also known as phylloquinone, is a fat-soluble vitamin essential for blood clotting, bone metabolism, and cardiovascular health. It functions as a cofactor for the enzyme γ-glutamyl carboxylase, which modifies clotting factors to enable calcium binding. Found abundantly in green leafy vegetables, Vitamin K₁ plays a critical role in synthesizing prothrombin and other coagulation proteins. It is also studied for its potential in supporting bone density and reducing arterial calcification, making it vital for both circulatory and skeletal health.

Reference

1:Association of Dietary Vitamin K1 Intake With the Incidence of Cataract Surgery in an Adult Mediterranean Population: A Secondary Analysis of a Randomized Clinical Trial. Camacho-Barcia ML, Bulló M, Garcia-Gavilán JF, Ruiz-Canela M, Corella D, Estruch R, Fitó M, García-Layana A, Arós F, Fiol M, Lapetra J, Serra-Majem L, Pintó X, García-Arellano A, Vinyoles E, Sorli JV, Salas-Salvadó J.JAMA Ophthalmol. 2017 May 11. doi: 10.1001/jamaophthalmol.2017.1076. [Epub ahead of print] PMID: 28494067 2:Non-Traditional Aspects of Renal Diets: Focus on Fiber, Alkali and Vitamin K1 Intake. Cupisti A, D/’Alessandro C, Gesualdo L, Cosola C, Gallieni M, Egidi MF, Fusaro M.Nutrients. 2017 Apr 29;9(5). pii: E444. doi: 10.3390/nu9050444. PMID: 28468236 Free Article3:Finding the optimal dose of vitamin K1 to treat vitamin K deficiency and to avoid anaphylactoid reactions. Mi YN, Ping NN, Li B, Xiao X, Zhu YB, Cao L, Ren JK, Cao YX.Fundam Clin Pharmacol. 2017 Apr 13. doi: 10.1111/fcp.12290. [Epub ahead of print] PMID: 28407450 4:Introduction of a carbon paste electrode based on nickel carbide for investigation of interaction between warfarin and vitamin K1. Torkashvand M, Gholivand MB, Taherpour AA, Boochani A, Akhtar A.J Pharm Biomed Anal. 2017 May 30;139:156-164. doi: 10.1016/j.jpba.2017.02.032. Epub 2017 Mar 1. PMID: 28284080 5:Multiplex assessment of serum cytokine and chemokine levels in idiopathic morphea and vitamin K1-induced morphea. Cox LA, Webster GF, Piera-Velazquez S, Jimenez SA.Clin Rheumatol. 2017 May;36(5):1173-1178. doi: 10.1007/s10067-017-3580-2. Epub 2017 Feb 20. PMID: 28220270 6:A sensitive and rapid UFLC-APCI-MS/MS bioanalytical method for quantification of endogenous and exogenous Vitamin K1 isomers in human plasma: Development, validation and first application to a pharmacokinetic study. Nannapaneni NK, Jalalpure SS, Muppavarapu R, Sirigiri SK.Talanta. 2017 Mar 1;164:233-243. doi: 10.1016/j.talanta.2016.11.056. Epub 2016 Nov 25. PMID: 28107923 7:Treatment of a long-acting anticoagulant rodenticide poisoning cohort with vitamin K1 during the maintenance period. Long J, Peng X, Luo Y, Sun Y, Lin G, Wang Y, Qiu Z.Medicine (Baltimore). 2016 Dec;95(51):e5461. doi: 10.1097/MD.0000000000005461. PMID: 28002326 Free PMC Article8:Development of isotope dilution-liquid chromatography/tandem mass spectrometry for the accurate determination of trans- and cis-vitamin K1 isomers in infant formula. Lee H, Lee J, Choi K, Kim B.Food Chem. 2017 Apr 15;221:729-736. doi: 10.1016/j.foodchem.2016.11.112. Epub 2016 Nov 22. PMID: 27979265 9:Vitamin D Status and Bone Mineral Density is Influenced by Vitamin D Supplementation and Vitamin K1 Intake in Adults with Diabetes and Chronic Kidney Disease. Hoffmann MR, Senior PA, Jackson ST, Ferland G, Presse N, Jindal K, Li P, Alzaben AS, Mager DR.Can J Diet Pract Res. 2017 Mar;78(1):11-19. doi: 10.3148/cjdpr-2016-023. Epub 2016 Oct 25. PMID: 27779902 10:Development of nanoemulsions for topical delivery of vitamin K1. Campani V, Biondi M, Mayol L, Cilurzo F, Pitaro M, De Rosa G.Int J Pharm. 2016 Sep 10;511(1):170-7. doi: 10.1016/j.ijpharm.2016.07.004. Epub 2016 Jul 4. PMID: 27386792