For research use only. Not for therapeutic Use.
VIT-2763（Cat No.:I015381）is an orally active, small-molecule ferroportin inhibitor designed to regulate systemic iron homeostasis. By selectively targeting ferroportin, the only known cellular iron exporter, VIT-2763 prevents iron release from enterocytes, macrophages, and hepatocytes, thereby reducing circulating iron levels. This mechanism is particularly relevant in conditions characterized by ineffective erythropoiesis and iron overload, such as β-thalassemia and related hematological disorders. With its oral bioavailability and specificity, VIT-2763 offers a promising therapeutic strategy for managing dysregulated iron metabolism and improving disease outcomes in preclinical and clinical research.
| CAS Number | 2095668-10-1 |
| Synonyms | 2-[2-[2-(1H-benzimidazol-2-yl)ethylamino]ethyl]-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide |
| Molecular Formula | C21H21FN6O2 |
| Purity | ≥95% |
| IUPAC Name | 2-[2-[2-(1H-benzimidazol-2-yl)ethylamino]ethyl]-N-[(3-fluoropyridin-2-yl)methyl]-1,3-oxazole-4-carboxamide |
| InChI | InChI=1S/C21H21FN6O2/c22-14-4-3-9-24-17(14)12-25-21(29)18-13-30-20(28-18)8-11-23-10-7-19-26-15-5-1-2-6-16(15)27-19/h1-6,9,13,23H,7-8,10-12H2,(H,25,29)(H,26,27) |
| InChIKey | KNYVRFXIVWUGBZ-UHFFFAOYSA-N |
| SMILES | C1=CC=C2C(=C1)NC(=N2)CCNCCC3=NC(=CO3)C(=O)NCC4=C(C=CC=N4)F |
| Chemistry Calculators | Dilution Calculator In vivo Formulation Calculator Molarity Calculator Molecular Weight Calculator Reconstitution Calculator |
