For research use only. Not for therapeutic Use.
VIP152 (Cat No.: I038070) is a highly selective cyclin-dependent kinase 9 (CDK9) inhibitor with potent anti-cancer activity. By targeting CDK9, it disrupts transcriptional regulation, particularly affecting oncogenic pathways dependent on RNA polymerase II, such as MYC-driven cancers. VIP152 induces apoptosis in tumor cells by inhibiting the expression of short-lived survival proteins. It is being investigated in clinical trials for hematologic malignancies and solid tumors. Its selectivity reduces off-target effects, making it a promising candidate for cancer therapy with improved safety and efficacy.
| CAS Number | 1610408-97-3 |
| Synonyms | VIP152; VIP-152; VIP 152; BAY 1251152; BAY1251152; BAY-1251152; |
| Molecular Formula | C19H18F2N4O2S |
| Purity | 98% |
| Solubility | To be determined |
| Appearance | Solid powder |
| Storage | Dry, dark and at 0 - 4 C for short term (days to weeks) or -20 C for long term (months to years). |
| IUPAC Name | (S)-((2-((5-fluoro-4-(4-fluoro-2-methoxyphenyl)pyridin-2-yl)amino)pyridin-4-yl)methyl)(imino)(methyl)-l6-sulfanone |
| InChI | InChI=1S/C19H18F2N4O2S/c1-27-17-8-13(20)3-4-14(17)15-9-19(24-10-16(15)21)25-18-7-12(5-6-23-18)11-28(2,22)26/h3-10,22H,11H2,1-2H3,(H,23,24,25)/t28-/m0/s1 |
| InChIKey | YZCUMZWULWOUMD-NDEPHWFRSA-N |
| SMILES | FC(C=N1)=C(C2=C(OC)C=C(F)C=C2)C=C1NC3=CC(C[S@](C)(=O)=N)=CC=N3 |
| Reference | 1: Lücking U, Kosemund D, Böhnke N, Lienau P, Siemeister G, Denner K, Bohlmann R, Briem H, Terebesi I, Bömer U, Schäfer M, Ince S, Mumberg D, Scholz A, Izumi R, Hwang S, von Nussbaum F. Changing for the Better: Discovery of the Highly Potent and Selective CDK9 Inhibitor VIP152 Suitable for Once Weekly Intravenous Dosing for the Treatment of Cancer. J Med Chem. 2021 Jul 15. doi: 10.1021/acs.jmedchem.1c01000. Epub ahead of print. PMID: 34264057. |
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