Vincamine

• CAT Number: I002071
• CAS Number: 1617-90-9
• Molecular Formula: C21H26N2O3
• Molecular Weight: 354.44
• Purity: ≥95%
• Synonyms: methyl (15S,17S,19S)-15-ethyl-17-hydroxy-1,11-diazapentacyclo[9.6.2.02,7.08,18.015,19]nonadeca-2,4,6,8(18)-tetraene-17-carboxylate
• InChI: InChI=1S/C21H26N2O3/c1-3-20-10-6-11-22-12-9-15-14-7-4-5-8-16(14)23(17(15)18(20)22)21(25,13-20)19(24)26-2/h4-5,7-8,18,25H,3,6,9-13H2,1-2H3/t18-,20+,21+/m1/s1
• InChIKey: RXPRRQLKFXBCSJ-GIVPXCGWSA-N
• SMILES: CCC12CCCN3C1C4=C(CC3)C5=CC=CC=C5N4C(C2)(C(=O)OC)O

Vincamine (Cat No.: I002071) is a naturally occurring alkaloid derived from the periwinkle plant Vinca minor, primarily used as a cerebral vasodilator and nootropic. It enhances blood flow to the brain, potentially improving oxygen and nutrient delivery, which may aid in cognitive function, especially in age-related decline. Vincamine is thought to modulate calcium channels and influence neurotransmitter systems. It is used in some countries as a treatment for vascular dementia and related disorders. Side effects may include hypotension, gastrointestinal discomfort, or mild nervous system effects.

Reference

[1]. Te Du, et al. Vincamine as a GPR40 agonist improves glucose homeostasis in type 2 diabetic mice. J Endocrinol. 2019 Feb 1;240(2):195-214.
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[2]. Li Wu, et al. Vincamine prevents lipopolysaccharide induced inflammation and oxidative stress via thioredoxin reductase activation in human corneal epithelial cells. Am J Transl Res. 2018 Jul 15;10(7):2195-2204. eCollection
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